[et_pb_section bb_built=”1″ inner_shadow=”on” fullwidth=”on” _builder_version=”3.21.4″ background_color=”#2ea3f2″ z_index_tablet=”500″ next_background_color=”#ffffff”][et_pb_fullwidth_header title=”Mission” _builder_version=”3.21.4″ background_color=”rgba(255, 255, 255, 0)” background_image=”https:\/\/www.fondationbarletta.org\/wp-content\/uploads\/2019\/04\/mission-banner.jpg” max_width_tablet=”50px” z_index_tablet=”500″ button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off”]<\/p>\n
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Targeted treatments for each patient<\/em><\/strong><\/span><\/p>\n Traditionally, treatment choices for the majority of cancer patients have been guided by the results of large-scale clinical studies, identifying the most efficient treatments for a maximum of patients. Treatment choices for an individual patient have typically been based on tumour site, histology, size and disease extent. This approach limits the outcomes for some tumours and does not account for possible effects of tumour evolution over time, nor the imprint of prior therapies in progressing or relapsing neoplasms.\u00a0<\/span><\/p>\n Over the last 30 years, accumulating cellular and molecular biology data have allowed us to better understand the sensitivity and resistance mechanisms of tumour cells to anticancer treatments. While the boom over the last decade in targeted therapies and immune checkpoint inhibitors has created options for personalised treatment for some mainstream cancer types, for infrequent tumour types this scientific knowledge remains poorly exploited.\u00a0<\/p>\n Each patient, tumour, and their interaction, are unique. Each disease tells its own story, and understanding the polymorphous nature of the disease via its biological and evolutive characteristics is essential.\u00a0\u00a0<\/span>The aim of individualised therapeutics is to implement the optimal therapeutic choice adapted to each patient\u2019s individual case using genomic, epigenetic, biological and histological data to identify specificities of the patient\u2019s tumour biology and clinical data.\u00a0This involves a shift of the research focus from drug and technology development to patient and tumour phenotype.<\/span><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”3.0.89″][et_pb_column type=”4_4″][et_pb_text module_id=”diagnostic” module_class=”title-zone” _builder_version=”3.21.4″]<\/p>\n [\/et_pb_text][et_pb_text _builder_version=”3.21.4″ z_index_tablet=”500″]<\/p>\n Optimising available biological data<\/em><\/strong><\/p>\n Collaborative efforts have resulted in large networks of tumour biobanks becoming available to the scientific community. However despite the large potential of this research material, important clinical information is often not available for oncologists to optimally exploit the data documented in tumour banks, such as the natural history of the disease, its evolution under a given treatment and the links between biopsies stored in paraffin and in biobanks. Furthermore, such biobanks and networks are typically devoted to the most prevalent cancers.<\/p>\n Concrete applications for phenotypic profiles<\/em><\/strong><\/p>\n Many available tests allow identification of specific phenotypic characteristics which are known therapeutic determinants. Correlating these results with the natural history and evolution of treated patients harbouring such characteristics, will take us a step closer to truly individualised therapeutics for future patients.\u00a0<\/span><\/p>\n Creating research networks and connections<\/em><\/strong><\/p>\n By publishing results and communicating information to teams directly implicated in personalised therapies, the FNAB contributes to developing translational medicine cooperative networks which can assist physicians worldwide, and to improving the flow and structure of information to obtain positive treatment outcomes.\u00a0Major advances have been seen with oncologists linking tumour biology research to their routine patient treatment. The FNAB aims to support new translational oncologists in centres of excellence to promote personalised therapeutics for patients with rare oncologic entities or clinically relevant sub-entities among prevalent neoplasms.<\/span><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" The FNAB\u2019s mission is to foster, promote and fund scientific research to enable individualised prognostic evaluation, and develop personalised anti-cancer therapeutics.\u00a0\u00a0\u00a0Our vision Targeted treatments for each patientTraditionally, treatment choices for the majority of cancer patients have been guided by the results of large-scale clinical studies, identifying the most efficient treatments for a maximum of patients. […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-689","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.fondationbarletta.org\/en\/wp-json\/wp\/v2\/pages\/689","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.fondationbarletta.org\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.fondationbarletta.org\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.fondationbarletta.org\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.fondationbarletta.org\/en\/wp-json\/wp\/v2\/comments?post=689"}],"version-history":[{"count":14,"href":"https:\/\/www.fondationbarletta.org\/en\/wp-json\/wp\/v2\/pages\/689\/revisions"}],"predecessor-version":[{"id":1350,"href":"https:\/\/www.fondationbarletta.org\/en\/wp-json\/wp\/v2\/pages\/689\/revisions\/1350"}],"wp:attachment":[{"href":"https:\/\/www.fondationbarletta.org\/en\/wp-json\/wp\/v2\/media?parent=689"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Achieving our objectives<\/h2>\n